Food Chemical Hazard Detection

Description: Food chemical safety remains a serious concern to the food industry. Risks such as adulteration, the existence of toxic and allergenic compounds in foods, and poor regulation of post harvest processing indicate that food chemical safety is not fully guaranteed. With the increasing trend of globalization in the import and export of food products, the importance of employing accurate and reliable analytical instruments to rapidly detect chemical hazards in foods has become paramount. In recent years, many new applications for using a range of analytical methods to detect food chemical hazards have emerged. Food Chemical Hazard Detection: Development and Application of New Technologies aims to cover the major developments and applications in this field. With a far-reaching scope, this book includes sections dedicated to chromatography tandem mass spectrometry, immunoassay, biophotonics, nanotechnology, biosensors and microfluidic based "lab-on-a-chip". A team of expert authors from major academic institutions in the USA, Canada and China bring a wealth of research experiences to bear in this major new work, which will be required reading for anyone interested in food chemical hazards and their effective detection and intervention strategies. Food Chemical Hazard Detection: Development and Application of New Technologies is aimed at a diverse audience, including food safety testing laboratories, scientists and managers in the global food supply chain, academic institutions, governmental regulatory agencies and food safety training providers. Readers will receive not only the fundamentals about different detection techniques, but will also gain insights into the current and future applications of each technique.



Contents: List of contributors xi

Preface xiii

Section I CHROMATOGRAPHY TANDEM MASS SPECTROMETRY1

1 Recent developments in gas chromatography massspectrometry for the detection of food chemical hazards 3 Renbang Zhao 3

1.1 The combination of gas chromatography and mass spectrometry3

1.1.1 Introduction 3

1.1.2 Basic gas chromatography 4

1.1.3 Typical mass analyzers and MS detectors in GC MS5

1.1.4 New development in GC MS and sample preparation6

1.2 Analysis of pesticide residues in foods 8

1.2.1 Sample preparation 8

1.2.2 Development of GC MS methods for the determinationof pesticides in foods 12

1.3 Analysis of contaminants formed during food processing18

1.3.1 Acrylamide 18

1.3.2 Heterocyclic amines 20

1.3.3 Furan 22

1.3.4 Polycyclic aromatic hydrocarbons (PAHs) 25

1.3.5 Tetramine 27

1.3.6 Chloropropanols 27

1.4 Analysis of environmental contaminants 30

1.4.1 Organometallic compounds 30

1.4.2 Polychlorinated biphenyls 31

1.4.3 Monocyclic aromatic hydrocarbons 34

1.5 Analysis of contaminants from packaging materials 35

1.6 Nitrite 39

Summary 40

Abbreviations 40

References 41

2 Recent developments in liquid chromatography massspectrometry for the detection of food chemical hazards53 Hongyan Zhang and Jinxing He 53

2.1 Introduction to food safety detection by liquidchromatography mass spectrometry 53

2.2 Principles and current technology of LC MS 55

2.2.1 Extraction and/or purification of specific analytes infood samples 55

2.2.2 Typical LC conditions for LC MS analysis 56

2.2.3 Mass spectrometry 57

2.2.4 Interface technology 58

2.2.5 Method validation and matrix effects 59

2.3 Applications of LC MS in food safety detection 60

2.3.1 Applications of LC MS in the analysis of veterinarydrugs and growth-promoting agents 60

2.3.2 Applications of LC MS in the analysis of pesticideresidue in foods 79

2.3.3 Applications of LC MS in the analysis of biotoxinsin foods 84

2.4 Conclusion 87

Abbreviations 87

References 89

Section II IMMUNOASSAYS 103

3 State of the art immunoassay developments and applicationto food chemical hazards 105 Xianghong Wang 105

3.1 Development and use of immunoassay to monitor food chemicalhazards 105

3.1.1 Chemical hazards in foods 105

3.1.2 Development of immunoassay in the detection of foodchemical hazards 107

3.2 Design and synthesis of haptens 108

3.3 Antibody production 112

3.3.1 Elementary knowledge of antibodies 112

3.3.2 Antibody classification 113

3.4 Immunoassay formats 115

3.4.1 Antigen antibody reaction 115

3.4.2 Immunoassay classification 120

3.5 Sample preparation from various matrices 126

3.6 Conclusion 127

References 128

4 Molecularly imprinted polymers (MIPs) an emergingtechnique for chemical hazard determination 137 Qiliang Deng and Shuo Wang 137

4.1 Introduction 137

4.2 Preparation of molecularly imprinted polymers 138

4.2.1 Template molecule 140

4.2.2 Functional monomer 140

4.2.3 Cross-linker monomer 141

4.2.4 Solvents 142

4.2.5 Initiator 143

4.2.6 Polymerization technique 143

4.3 Molecularly imprinted solid-phase extraction modes 145

4.3.1 Off-line mode 146

4.3.2 On-line mode 147

4.4 Applications of MISPE in food chemical hazard determination148

4.4.1 Determination of drug residues 148

4.4.2 Determination of pesticides 155

4.4.3 Determination of herbicides 156

4.4.4 Determination of additives 158

4.4.5 Determination of environmental contaminants 161

4.5 Conclusion and outlook 161

References 162

Section III BIOPHOTONICS 173

5 Recent developments in infrared spectroscopy for thedetection of food chemical hazards 175 Xiaonan Lu 175

5.1 A brief introduction to infrared spectroscopy and itsapplication in the food industry 175

5.2 Application of IR spectroscopy to detect chemicaladulterants in foods 177

5.3 Application of IR spectroscopy to detect mycotoxins in foods178

5.4 Application of IR spectroscopy to detect pesticides in foods181

5.5 Application of IR spectroscopy to detect antibiotic residuesin foods 181

5.6 Tips for reporting results 182

5.7 Trends in IR instrumentation 184

5.8 Trends in further applications of chemometrics to analyze IRspectra 186

5.9 Conclusion 186

References 186

6 Recent developments in Raman spectroscopy for the detectionof food chemical hazards 191 Lili He 191

6.1 Introduction 191

6.1.1 Raman theory 191

6.1.2 Raman instrumentation and data analysis 192

6.1.3 Surface-enhanced Raman spectroscopy 193

6.2 Detection of chemicals in simple solvents 194

6.3 Detection of chemicals in food matrices 196

6.3.1 Detection of small chemical molecules in food matrices196

6.3.2 Detection of large protein molecules in food matrices199

6.4 Conclusion and outlook 203

References 204

Section IV NANOTECHNOLOGY 207

7 Engineered nanoparticles (ENPs): applications, riskassessment, and risk management in the agriculture and food sectors209 Mahmoudreza Ovissipour, Syamaladevi M. Roopesh, Barbara A.Rasco

and Shyam S. Sablani 209

7.1 Introduction 209

7.2 Naturally occurring nanoparticles 211

7.3 Nanoparticle engineering 213

7.4 Engineered nanoparticles (ENPs) 214

7.5 Applications of ENPs in the agriculture and food sectors216

7.5.1 Applications of ENPs in agriculture 217

7.5.2 Antimicrobial applications of ENPs 223

7.5.3 Applications of encapsulated ENPs in foods 225

7.5.4 Applications of ENPs in food packaging 225

7.6 Nanosensors 227

7.7 Impacts of ENPs on the environment 228

7.8 Risk assessment and risk management of ENPs in foodtechnology 233

7.9 Future trends 235

References 236

8 Nanotechnology and its applications to improve thedetection of chemical hazards in foods 249 Mengshi Lin 249

8.1 Introduction 249

8.2 Nanomaterials used in sensors 250

8.3 Chemical hazards in foods 251

8.3.1 Pesticides 251

8.3.2 Veterinary drugs 253

8.3.3 Bisphenol A 255

8.3.4 Melamine 256

8.3.5 Acrylamide 258

8.4 Conclusion 258

References 258

Section V BIOSENSORS 263

9 Microfluidics lab-on-a-chip system for foodchemical hazard detection 265 Jie Xu 265

9.1 Microfluidics and lab-on-a-chip 265

9.2 Fluid mechanics at the microscale 266

9.3 Microfabrication technologies 269

9.4 Detection techniques 272

9.5 Representative applications in the detection of chemicalhazards in foods 272

9.6 Future perspectives 279

References 280

10 Colorimetric biosensor for food chemical hazards detection291 Jianlong Wang and H. Susan Zhou 291

10.1 Introduction 291

10.2 Detection of hazardous chemicals in foods usingcolorimetric biosensors based on bio-nanomaterials 293

10.2.1 Colorimetric detection of pesticides 295

10.2.2 Colorimetric detection of veterinary drugs 298

10.2.3 Colorimetric detection of heavy metal ions 301

10.2.4 Colorimetric detection of food additives 303

10.2.5 Colorimetric detection of toxins 305

10.2.6 Colorimetric detection of other hazardous chemicalcontaminants 305

10.3 Conclusion 306

Acknowledgments 307

References 307

Index 315



Author Biography:

Professor Shuo Wang is President of Tianjin University of Science and Technology, Director of Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, and Cheung Kong Scholar. He is also the recipient of Chinese National Science Fund for Distinguished Young Scholars in 2012.