Silicon-Mediated Transformation Of Functional Groups

Description:
In the first work to comprehensively cover this all-important topic, the recognized expert Helmut Vorbreggen provides both organic and bioorganic chemists with much new and valuable information for preparative synthesis. Although every organic chemist may be familiar with different aspects of silylation for the protection of functional groups, this book covers the concept of protection while simultaneously silylating-activating various functional groups, such as amides and ureas. This novel methodology opens thus numerous synthetic pathways while effecting the elimination of water in it volatile persilylated form under rather mild reaction conditions, which are often advantageous compared to conventional methods.The compact form and clear structure of this monograph make this a long-awaited ready reference. The contents include: Introduction; Techniques of Preparative Silylations-Desilylations; Preparation and Properties of Siliconoxy-Leaving Groups; Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide; Reactions of Aldehydes and Ketones; Reactions of Alcohols, Ethers and Epoxides; Reaction of N-O Systems; Reactions of S-O and Se-O Systems; Cyclizations and Ring Enlargements; Base and Acid-Catalyzed as well as Thermal Eliminations of Trimethylsilanol; Peterson Reactions; Formation of Carbon-Phosphorous Double- and Triple Bonds; Reductions and Oxidations; Dehydration-Activation as well as Silylation of Inorganic and Organic Salts and Metalorganic Compounds; and, Formation of Polymers.

Review:
'...very informative and should be of great interest to practicing organic chemists.' (Journal of the American Chemical Society, October 26, 2005) 'This handbook is a clear, compact compilation ... an essential practical and reference book for the research chemist.' (Applied Organometallic Chemistry, May 2005)

Table of Contents:
Preface.1. Introduction.2. Techniques of Preparative Silylation-Desilylations.3. Preparation and Properties of Siliconoxy Leaving Groups.4. Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide.5. Reactions of Aldehydes and Ketones.6. Reactions of Alcohols, Ethers, Silyl Ethers, Epoxides, and Haloalkanes.7. Reactions of N-O Systems.8. Reactions of S-O and Se-O Systems.9. Cyclizations and Ring Enlargements.10. Base-catalyzed, Acid-catalyzed and Thermal Eliminations of Trimethylsilanol, Peterson Reactions.11. Formation of Carbon-Phosphorous Double Bonds.12. Reductions and Oxidations.13. Dehydration-Halogenation-Activation and Silylation of Inorganic and Organic Salts and Metallorganic Compounds.14. Formation of Organic and Inorganic Polymers.Appendix.Subject Index.Author Index.

Author Biography:
Helmut Vorbruggen Born in 1930, Helmut Vorbruggen received his Ph.D. in organic chemistry at the University of Gottingen, Germany, working with H. Brockmann (1956-1958). He held research assistant positions at the Royal Institute of Technology in Stockholm, Sweden with H. Erdtman, at Stanford University, California, USA with C. Djerassi, and at the Woodward Research Institute in Basel, Switzerland with R.B. Woodward. From 1966 until 1995 he was department head at central research of Schering AG in Berlin, Germany, as well as from 1973-1994 Adjunct Professor of Organic Chemistry at the Technical University, Berlin and from 1995-2004, Visiting Professor at the Department of Organic Chemistry, Free University, Berlin. Professor Vorbruggen is the author and editor of more than 120 articles, reviews, and monographs and has introduced new synthetic methods as well as new reagents such as trimethylsilyl triflate into preparative organic chemistry.