Platelets In Hematologic And Cardiovascular Disorders

Description:
A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

Review:
'Think of a platelet-related topic and the chances are that this book will have it covered along with useful references. The editors have done an excellent job in recruiting experts to write each chapter. The chapters can stand independently, but yet they gel nicely together. ... We were able to find the most unlikely facts even on laboratory aspects of platelet function assessment. There is also excellent and diverse information on the clinical role of platelets in haematologic and cardiovascular disorders. ... The chapters are well organised with user-friendly tables and the detailed colour illustrations are a great bonus. ... Overall this is an excellent reference tool that is also very readable. A 'must buy' for all those involved with platelets!' Platelets '...an excellent handbook that provides a wide range of information in a complete and clear but concise way that will serve as a comprehensive and authoritative guide to the diagnosis and therapeutics of diseases involving platelets. An interesting additional bonus is the accessibility of additional illustrative and textual materials that can be found at http://www.cambridge.org/gresele.' International Journal of Emergency Medicine 'This book actually is not simply an updated version of the previous, excellent, book by the same Editors ... but represents a completely new book with several important conceptual and organisational changes. ... The Editors are all involved in studies on platelets at the highest level and coming from different disciplines (Internal Medicine, Pharmacology, Cardiology, Haematology) provide different angles to the subject of the book. The book is handy and well published, with coloured pages and clearly marked tables, headings and subheadings which makes it easy to consult and remember. ... Overall this is an excellent handbook that provides a wide range of informations in a complete and clear, but concise, way that will serve as a comprehensive and authoritative guide to the diagnosis and therapeutics of diseases involving platelets. AN interesting additional bonus is the accessibility of additional illustrative and textual materials that can be found at http://www.cambridge.org/gresele.' Internal and Emergency Medicine

Table of Contents:
Preface; 1. The structure and production of blood platelets Joseph E. Italiano, Jr; 2. Platelet immunology: structure, functions and polymorphisms of membrane glycoproteins Yasuo Ikeda, Yumiko Matsubara and Tetsuji Kamata; 3. Mechanisms of platelet activation Lawrence Brass and Timothy J. Stalker; 4. Platelet priming Paolo Gresele, Emanuela Dalcinelli and Stafania Momi; 5. Platelets and coagulation Jose A. Lopez and Ian del Conde; 6. Vessel-wall-derived substances affecting platelets Azad Raiesdana and Joseph Loscalzo; 7. Platelet-Leukocyte-Endothelial cross talk Kevin J. Croce, Masashi Sakuma and Daniel I. Simon; 8. Laboratory investigation of platelets Eduard Shantsila, Timothy Watson and Gregory Y. H. Lip; 9. Clinical approach to the bleeding patient Jos Vermylen and Kathelijne Peerlinck; 10. Thrombocytopenia James Bussel and Andrea Primiani; 11. Reactive and clonal thrombocytosis Ayalew Tefferi; 12. Congenital disorders of platelet function Marco Cattaneo; 13. Acquired disorders of platelet function Michael H. Kroll and Amy A. Hassan; 14. Platelet transfusion therapy Sherrill J. Slichter and Ronald G. Strauss; 15. Clinical approach to the patient with thrombosis Brian G. Choi and Valentin Fuster; 16. Pathophysiology of arterial thrombosis Juan Jose Badimon, Borja Ibanez and Gemma Vilahur; 17. Platelets and atherosclerosis Stephan Lindemann and Meinrad Gawaz; 18. Platelets in other thrombotic conditions David L. Green, Peter W. Marks and Simon Karpatkin; 19. Platelets in respiratory disorders and inflammatory conditions Paolo Gresele, Stefania Momi, Simon C. Pitchford and Clive P. Page; 20. Platelet pharmacology Dermot Cox; 21. Antiplatelet therapy versus other antithrombotic strategies Nicolai Mejevoi, Catalin Boiangiu and Marc Cohen; 22. Laboratory monitoring of antiplatelet therapy Paul Harrison and David Keeling; 23. Antiplatelet therapy in cardiology Pierluigi Tricoc and Robert A. Harrington; 24. Antiplatelet therapy in cerebrovascular disease James Castle and Gregory W. Albers; 25. Antiplatelet treatment in peripheral arterial disease Raymond Verhaeghe and Peter Verhamme; 26. Antiplatelet treatment of venous thromboembolism Menno V. Huisman, Jaapjan D. Snoep, Jouke T. Tamsma and Marcel M. C. Hovens; Index.

Author Biography:
Paolo Gresele is a Professor of Internal Medicine at the University of Perugia, Italy. Valentin Fuster is the Director of Mount Sinai Heart School of Medicine, New York. Jose A. Lopez is the Executive Vice President for Research at the University of Seattle, Washington. Clive P. Page is a Professor of Pharmacology at King's College London. Jos Vermylen is an Emeritus Professor of Medicine at the University of Leuven, Belgium.