Anesthetic Pharmacology

Description:
In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, second edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Review:
Anesthesiology

Table of Contents:
Preface to the first edition; Preface to the second edition; Part I. Principles of Drug Action: 1. Pharmacodynamic principles of drug action; 2. G protein coupled receptors; 3. Other signalling pathways; 4. Signal transduction mechanisms: ion channels; 5. Principles of pharmacokinetics; 6. Principles of drug transformation; 7. Drug transport and transporters; 8. Target controlled infusions and closed loop administration; 9. Alternate routes of drug administration; 10. Principles of pharmacogenetics; 11. Pharmacodynamic drug interactions in anesthetic practice; 12. Pharmacoeconomics; Part II. Physiologic Substrates of Drug Action: 13. Sleep and consciousness; 14. Synaptic transmission; 15. Memory, learning and cognition; 16. Mechanisms of pain transmission and transduction; 17. Generation and propagation of action potentials; 18. Neuromuscular junction; 19. Vascular reactivity; 20. Cardiac rhythm; 21. Myocardial performance; 22. Autonomic function; 23. Physiology of immunity and inflammation; Part III. Essential Drugs in Anesthetic Practice: 24. Mechanisms of anesthetic action; 25. Pharmacokinetics of inhaled anesthetics; 26. Clinical pharmacology of inhaled anesthetics; 27. Pharmacokinetics of intravenous anesthetics; 28. Clinical pharmacology of intravenous anesthetics; 29. Benzodiazepines; 30. alpha-2 Agonists and other sedatives and amnestics; 31. Mechanisms of action of opioids; 32. Pharmacokinetics of opioids; 33. Clinical pharmacology of opioids; 34. Nonsteroidal anti-inflammatory drugs; 35. Other ion channel and receptor ligands for analgesia; 36. Local anesthetics; 37. Anticonvulsant and antipsychotic drugs; 38. Neuromuscular blocking agents; 39. Reversal drugs; 40. Sympathomimetics and vasoconstrictors; 41. Parasympathomimetic and parasympatholytic drugs; 42. beta-blockers and other adrenergic receptor antagonists; 43. Antiarrhythmic agents; 44. Positive inotropic drugs; 45. Vasodilators (incl. ACE inhibitors and NO); 46. Calcium channel blockers; 47. Bronchodilators; 48. Pulmonary vasodilators; 49. Drugs acting via the kidney; 50. Fluids and electrolytes as pharmacologic agents; 51. Corticosteroids and anti-inflammatory agents; 52. Anti-rejection drugs and immunosuppressants; 53. Antimotility and antisecretory agents; 54. Antiemetics; 55. Insulin and anti-hyperglycemic agents; 56. Nutritional elements of management; 57. Agents affecting coagulation and platelet function; 58. Obstetrical adjuvants and obstetric pharmacology; 59. Antimicrobial therapy; Part IV. Clinical Application and Anesthesia Practice (Evidence Based, Rational Drug Selection, Management): 60. Pre-operative management; 61. Induction of anesthesia; 62. Maintenance and emergence from anesthesia; 63. Management of sedation, analgesia and delirium; 64. Post-operative analgesia; 65. Control of blood pressure and vascular tone; 66. Cardiac protection and pharmacologic management of myocardial ischemia; 67. Management of patients with chronic alcohol or drug use; 68. Drug allergy and treatment; 69. Special populations - pediatric; 70. Special populations - geriatric; 71. Emerging concepts: neuroprotection and neurotoxicity; Index.

Author Biography:
Alex S. Evers is Henry E. Mallinckrodt Professor of Anesthesiology, and Professor of Internal Medicine and Molecular Biology and Pharmacology, Washington University School of Medicine, USA. Professor Mervyn Maze is Chair, Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA. Evan Kharasch is Russell D. and Mary B. Shelden Professor of Anesthesiology, Director, Division of Clinical and Translational Research, Department of Anesthesiology, and Professor of Biochemistry and Molecular Biophysics, Washington University, USA.