Organic Synthesis: Strategy And Control

Description: Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. * A comprehensive, practical account of the key concepts involved in synthesising compounds * Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations * Focuses on reactions that really work rather than those with limited application * Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis. Review: 'Of interest to the experienced practitioner looking to broaden (or reawaken) awareness of the remarkable diversity of available synthetic transformations'(Journal of Medicinal Chemistry, 2008) Table of Contents: A: Introduction: Selectivity. 1. Planning Organic Syntheses: Tactics, Strategy, and Control. 2. Chemoselectivity. 3. Regioselectivity: Controlled Aldol Reactions. 4. Stereoselectivity: Stereoselective Aldol Reactions. 5. Alternative Strategies for Enone Synthesis. 6. Choosing a Strategy : The Synthesis of cyclopentenones. B: Making Carbon-Carbon Bonds. 7. The Ortho Strategy for Aromatic Compounds. 8. delta-Complexes of Metals. 9. Controlling the Michael Reaction. 10. Specific Enol Equivalents. 11. Extended Enolates. 12. Allyl Anions. 13. Homoenolates. 14. Acyl Anion Equivalents. C: Carbon-Carbon Double Bonds. 15. Synthesis of Double Bonds of Defined Stereochemistry. 16. Stereo-Controlled Vinyl Anion Equivalents. 17. Electrophilic Attack on Alkenes. 18. Vinyl Cations: Palladium-Catalysed C-C Coupling. 19. Allyl Alcohols: Allyl Cation Equivalents (and More). D: Stereochemistry. 20. Control of Stereochemistry - Introduction. 21 Controlling Relative Stereochemistry. 22. Resolution. 23. The Chiral Pool. 24. Asymmetric Induction I: Reagent-Based Strategy. 25. Asymmetric Induction II: Asymmetric Catalysis: Formation of C-O and C-N Bonds. 26. Asymmetric Induction III: Asymmetric Catalysis: Formation of C-H and C-C Bonds. 27. Asymmetric Induction IV: Substrate-Based Strategy. 28. Kinetic Resolution. 29. Enzymes: Biological Methods in Asymmetric Synthesis. 30. New Chiral Centres from Old. 31. Strategy of Asymmetric Synthesis. E: Functional Group Strategy. 32. Functionalisation of Pyridine. 33. Oxidation of Aromatic Compounds, Enols and Enolates. 34. Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements. 35. Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms. 36. Tandem Organic Reactions. General References. Index. Author Biography: Paul Wyatt, Senior Lecturer and Director of Undergraduate Studies, School of Chemistry, University of Bristol, UK and Stuart Warren, Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.