Chemistry And Molecular Aspects Of Drug Design And Action

Description:
Drawing from synthetic chemistry, molecular modeling, computational biology, structural genomics, and pharmacology, this text fully explores medicinal chemistry. With a chemical-molecular perspective, it focuses on the correlation of properties and biological activity, and delves into the phenomenon of xenobiotic metabolism. Written by experts representing various research fields, 'Medicinal Chemistry' addresses current epidemiological, scientific, social, and economic concerns, and considers approaches to Alzheimer's, HIV, addiction, and environmental chemical toxicity, as well as cardiovascular, psychological, and neurological disorders. It also examines approaches to rational drug design.

Table of Contents:
Introduction: Rational Drug Design Based Mainly on the Pathobiochemistry of the Disease, E.A. Rekka, A.P. Kourounakis, and P.N. Kourounakis Part I: Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Inflammatory Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders, J. Rogers, T. Beach, R. Li, Z. Liang, L.-F. Lue, A. Roher, M. Sabbagh, Y. Shen, R. Strohmeyer, and D. Walker Treatment Development Strategies for Alzheimer's Disease, E. Wulfert Lipoprotein-Associated Phospholipase A2 as a New Prognostic Factor for Coronary Artery Disease, A.D. Tselepis New Molecular Targets for the Prevention and Treatment of Gastrointestinal Ulcers and Inflammation S. Szabo, G. Tolstanova, L. Nagy, L. Chen, T. Khomenko, X. Deng, and Z. Sandor Stress Activates Corticotropin Releasing: Factor Signaling Pathways: Implication in Functional Bowel Disorders, Y. Tache Part II Classical Medicinal Chemistry Design, Synthesis, and Pharmacological Evaluation of High-Affinity and Selectivity Sigma-1 and Sigma-2 Receptor Ligands, J.H. Poupaert Synthesis of Biologically Active Taxoids, K.C. Nicolaou and R.K. Guy From the Molecular Pharmacology to the Medicinal Chemistry of Cannabinoids, D.M. Lambert An Appraisal of Fomocaines: Current Situation and Outlook, H. Oelschlager and A. Seeling Ligands for the GABA Recognition Site at the GABAA Receptor: Structure-Activity Studies, B. Frolund, U. Kristiansen, P. Krogsgaard-Larsen, and T. Liljefors Strategies for Development of New Lead Structures for Inhibition of Acetylcholinesterase, P. Kapkova, V. Alptuzun, E. Heller, E. Kugelmann, G. Folkers, and U. Holzgrabe Part III Drug Design, Chemical and Molecular Aspects of Drug Action Discovery of Potent and Selective Inhibitors of Human Aldosterone Synthase (CYP11B2): A New Target for the Treatment of Congestive Heart Failure and Myocardial Fibrosis--a Review, R.W. Hartmann, U. Muller-Vieira, S. Ulmschneider, and M. Voets Thiocarboxanilides: A New Class of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) with Great Potential for the Treatment of Human Immunodeficiency Virus Type 1 (HIV-l) Infections, E. De Clercq, A. Karlsson, and J. Balzarini Histamine H3-Receptor Agonists and Antagonists: Chemical, Pharmacological, and Clinical Aspects, H. Stark and W. Schunack Anti-Inflammatory Actions of Flavonoids and Structural Requirements for New Design, T.C. Theoharides Molecular Mechanisms of H2O2-Induced DNA Damage: The Action of Desferrioxamine, M. Tenopoulou, P.-T. Doulias, and D. Galaris LNA (Locked Nucleic Acid) and Functionalized LNA: Toward Efficient Gene Targeting, J. Wengel Part IV Drug -- Xenobiotic Metabolism The Effect of Diet on Drug Metabolism, K.J. Netter Cytochromes P450 in the Metabolism and Bioactivation of Chemicals, C. Ioannides In Vitro Methods to Measure Drug Metabolism and Drug Interactions in Drug Discovery and Development, O. Pelkonen, M. Turpeinen, J. Uusitalo, P. Taavitsainen, and H. Raunio Part V Physical Organic and Theoretical Medicinal Chemistry How to Probe the Sites of Action of Drug Molecules, A. Makriyannis and F. Bitter Physicochemical Profiling in Early Drug Discovery: New Challenges at the Age of High-Throughput Screen and Combinatorial Chemistry, B. Faller Drug-Membrane Interaction and Its Importance for Drug Efficacy, J.K. Seydel, E.A. Coats, K. Visser, and M. Wiese The Fight Against AIDS: New Avenues for Inhibiting Reverse Transcriptase (RT), an Old Target, M. Botta, L. Angeli, M. Radi, and G. Maga