Bioanalytical Separations

Description:
'Bioanalytical Separations' is volume 4 of the multi-volume series, 'Handbook of Analytical Separations', providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. It discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids. It provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use. Future trends are identified, in terms of the potential impact of new technologies.

Review:
'This is a well-written and informative volume. It brings the reader up to date on a wide range of issues pertaining to separation methods in bioanalysis with special emphasis on sample preparation and LC-MS... This book should be of high value for scientists working with drug analysis in biological fluids.' Alexander Nezlin, The Alchemist, February 2004.

Table of Contents:
New developments in integrated sample preparation for bioanalysis, M.J.W. van Hout; solid-phase extraction on molecularly imprinted polymers, L.I. Andersson; techniques for sample preparation, using sold-phase extraction, U.D. Neue; turbulent flow chromatography in bioanalysis, D.M. Wallworth; method in reversed-phase chromatography, U.D. Neue; immobilized enzyme reactors in liquid chromoatography - on-line bioreactors for use in synthesis and drug discovery, I.W. Wainer; use of liquid chromatography- mass spectrometry in acute human toxicology, M.J. Bogusz; biomedical applications of directly-coupled chromatography - nuclear magnetic resonance spectroscopy and mass spectroscopy, J.C. Lindon; ultra-sensitive detection of radiolabelled drugs and their metabolites using accelerator mass spectrometry as an element specific detector for chromatographic separations, F.R. Abou-Shakra; chromatography in a regulated environment, H.M. Hill.